The Principal Research Scientist in Medicinal Chemistry at Elanco will play a crucial role in the small molecule drug discovery process, focusing on the design and synthesis of innovative medicines for animal health. This position involves collaboration with a global team of scientists and the application of advanced technologies such as AI/ML and DNA-Encoded Libraries. The role is based in Indianapolis and offers a hybrid work environment. The successful candidate will contribute significantly to the discovery portfolio and help shape the future of the research team.

• PhD in Medicinal Chemistry, Organic Chemistry, or a related scientific discipline.
• A minimum of 6 years of relevant industry experience in medicinal chemistry within a pharmaceutical, biotechnology, or animal health research environment.
• Demonstrated expertise in modern medicinal chemistry, including the design and multi-step synthesis of complex small molecules.
• Strong understanding of Structure-Activity Relationships (SAR), pharmacology, and ADME/PK principles.

• Guide the design and optimization of novel small molecules by applying advanced synthetic strategies.
• Serve as a key medicinal chemistry figure on multidisciplinary project teams.
• Manage and coordinate synthetic chemistry efforts with external Contract Research Organizations (CROs) and internal partners.
• Leverage cutting-edge drug discovery technologies to accelerate hit identification and lead optimization.
• Promote scientific excellence and data integrity while providing mentorship and technical guidance to junior scientists.

• Employees at Elanco are often offered competitive compensation with annual bonus and equity eligibility, retirement plans (including a U.S. 401(k)), and comprehensive health coverage—medical, dental, vision, company-paid life and disability—and even pet insurance. Time-off and flexibility typically include generous PTO, U.S. mid-year and year-end paid shutdown weeks, parental leave, and flexible/remote work options. Employees also benefit from strong development programs (onboarding, course libraries, mentorship, nine ERGs, and tiered leadership programs) that support both professional growth and community involvement.